全文获取类型
收费全文 | 504篇 |
免费 | 31篇 |
专业分类
林业 | 23篇 |
农学 | 13篇 |
基础科学 | 5篇 |
81篇 | |
综合类 | 69篇 |
农作物 | 16篇 |
水产渔业 | 28篇 |
畜牧兽医 | 262篇 |
园艺 | 19篇 |
植物保护 | 19篇 |
出版年
2023年 | 7篇 |
2022年 | 4篇 |
2021年 | 4篇 |
2020年 | 14篇 |
2019年 | 21篇 |
2018年 | 13篇 |
2017年 | 11篇 |
2016年 | 9篇 |
2015年 | 11篇 |
2014年 | 11篇 |
2013年 | 36篇 |
2012年 | 25篇 |
2011年 | 36篇 |
2010年 | 19篇 |
2009年 | 8篇 |
2008年 | 26篇 |
2007年 | 28篇 |
2006年 | 27篇 |
2005年 | 35篇 |
2004年 | 23篇 |
2003年 | 33篇 |
2002年 | 20篇 |
2001年 | 11篇 |
2000年 | 4篇 |
1999年 | 6篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1996年 | 2篇 |
1994年 | 2篇 |
1992年 | 4篇 |
1991年 | 6篇 |
1990年 | 6篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1986年 | 5篇 |
1985年 | 6篇 |
1983年 | 5篇 |
1982年 | 2篇 |
1980年 | 2篇 |
1979年 | 5篇 |
1978年 | 6篇 |
1976年 | 4篇 |
1975年 | 4篇 |
1969年 | 2篇 |
1967年 | 4篇 |
1934年 | 1篇 |
1917年 | 1篇 |
1916年 | 1篇 |
1915年 | 1篇 |
1912年 | 1篇 |
排序方式: 共有535条查询结果,搜索用时 718 毫秒
71.
The protozoan parasite, Eimeria leuckarti was present in the ileal mucosa of a 7-month-old Thoroughbred filly which was destroyed with acute peritonitis resulting from perforation of the rectum. The parasite was considered to be of no clinical significance and the signs of colic noted prior to the rectal rupture were related to the vascular lesions caused by infection with Delafondia vulgaris. 相似文献
72.
Abstract Extract Sir,—Japanese workers (Matumoto el al., 1965) have examined 388 horse sera from 17 countries including New Zealand and have found evidence of a high incidence of infection with equine rhinopneumonitis virus. The New Zealand material was supplied between 1957 and 1960, by Dr J. D. Manning, then of the National Health Institute, Wellington. 相似文献
73.
74.
Seelig DM Whittemore JC Lappin MR Myers AM Avery PR 《Journal of the American Veterinary Medical Association》2008,232(8):1181-1185
CASE DESCRIPTION: A 16-week-old female Boxer that had been treated for 5 weeks with trimethoprim-sulfamethoxazole and chloramphenicol because of aspiration pneumonia was evaluated for bilaterally symmetric masses in the subcutaneous tissues of the ventral neck, in the region of the larynx. CLINICAL FINDINGS: Fine-needle aspirates were obtained from the neck masses; cytologic examination revealed well-differentiated thyroid epithelial tissue. A blood sample was collected for serum biochemical and thyroid function analyses. Mild hyperphosphatemia, severe hypercholesterolemia, mild hyperkalemia, and a mild increase in creatine kinase activity were identified. Serum concentration of total thyroxine was less than the lower reference limit, and that of thyroid-stimulating hormone was greater than the upper reference limit. Findings were consistent with a diagnosis of clinical hypothyroidism in a skeletally immature dog. TREATMENT AND OUTCOME: Treatment with trimethoprim-sulfamethoxazole was discontinued. The dog was reevaluated 3 weeks later, at which time the neck masses were markedly decreased in size. Serum concentrations of cholesterol and potassium were lower; serum concentrations of total thyroxine and thyroid-stimulating hormone were near or within respective reference ranges. Age-appropriate increases in serum phosphorus concentration and serum alkaline phosphatase activity were also detected. CLINICAL RELEVANCE: To the authors' knowledge, this is the first report of antimicrobial-induced goiter in a dog. Cytologic examination of fine-needle aspirates and interpretation of data from serum biochemical and thyroid function analyses were needed to obtain a definitive diagnosis. Practitioners should include goiter among the differential diagnoses for ventral neck swellings in young dogs receiving potentiated sulfonamide antimicrobials. 相似文献
75.
Pearce BH Fosgate GT Ward MP Roussel AJ Norby B Tavornpanich S Ellis D 《Preventive veterinary medicine》2008,86(1-2):1-7
Surveillance and monitoring are important for measuring the level of disease in a population, documenting changes in prevalence over time, determining high-risk areas for implementation of control measures, eradicating disease, and documenting freedom from disease. The documentation of freedom from disease has importance for international trade and the resumption of production after an outbreak. Johne's disease (JD) is an example of an endemic disease of cattle that has variable prevalence related to environmental and animal-level factors. Three methods of sample collection were used to describe the prevalence and distribution of JD seropositivity in Texas. Sampled cattle were: (1) extensively managed herds, (2) market cattle, and (3) clinically ill cattle examined by practicing veterinarians throughout Texas. Samples were evaluated for JD using a commercially available serum ELISA. Proportion of seropositive samples was compared and spatial distributions were evaluated for clustering. Difference of JD seropositivity was observed among the three sample populations suggesting that estimation of disease prevalence is dependant upon the source of samples. 相似文献
76.
Elizabeth A. Giuliano Ian MacDonald† Dudley L. McCaw‡ Thomas J. Dougherty† Gia Klauss§ Juri Ota Jacqueline W. Pearce Philip J. Johnson 《Veterinary ophthalmology》2008,11(S1):27-34
Objective Local photodynamic therapy (PDT) is a novel cancer therapy in veterinary ophthalmology. A prospective pilot study seeking to demonstrate proof of principle and safety for the treatment of equine periocular squamous cell carcinoma (PSCC) was therefore conducted. We hypothesized that surgical excision with adjunctive local PDT is an effective and safe treatment for equine PSCC.
Procedures Nine horses (10 eyes) with PSCC were treated with surgical resection, local infiltration of resulting wound beds with 2-[1-hexyloxyethyl]-2-devinylpyropheophorbide-a (HPPH) and irradiation with 665-nm wavelength diode laser. Regular follow-up ophthalmic examinations were performed.
Results Surgical resection and PDT yielded disease-free intervals of 25–68 months in our study horses as of January, 2008. These results were obtained following a single treatment in seven horses and two treatments in one horse. In one horse, carcinoma in situ developed 2.5 months after partial surgical excision and PDT, requiring local excision under standing sedation.
Conclusions Preliminary results suggest that surgical resection and adjunctive local PDT is a safe and effective novel treatment for PSCC in horses. More research is needed before PDT for the treatment of equine PSCC can be adequately compared with other current modalities. Important to future investigations regarding PDT, tumor recurrence rate, length of hospitalization, number of treatment episodes required to effect tumor remission, and total treatment costs should be examined in a controlled manner. Our present results and experiences suggest that this treatment may be useful in the treatment of equine PSCC. 相似文献
Procedures Nine horses (10 eyes) with PSCC were treated with surgical resection, local infiltration of resulting wound beds with 2-[1-hexyloxyethyl]-2-devinylpyropheophorbide-a (HPPH) and irradiation with 665-nm wavelength diode laser. Regular follow-up ophthalmic examinations were performed.
Results Surgical resection and PDT yielded disease-free intervals of 25–68 months in our study horses as of January, 2008. These results were obtained following a single treatment in seven horses and two treatments in one horse. In one horse, carcinoma in situ developed 2.5 months after partial surgical excision and PDT, requiring local excision under standing sedation.
Conclusions Preliminary results suggest that surgical resection and adjunctive local PDT is a safe and effective novel treatment for PSCC in horses. More research is needed before PDT for the treatment of equine PSCC can be adequately compared with other current modalities. Important to future investigations regarding PDT, tumor recurrence rate, length of hospitalization, number of treatment episodes required to effect tumor remission, and total treatment costs should be examined in a controlled manner. Our present results and experiences suggest that this treatment may be useful in the treatment of equine PSCC. 相似文献
77.
Ruth A. Parsley Adrian G. Mutlow Jacqueline Hansted Femke J. Taverne Lisa A. Tell Ronette Gehring 《Journal of veterinary pharmacology and therapeutics》2019,42(1):74-84
Aspergillosis is a condition causing serious morbidity and mortality in captive penguins and other bird species. It can be treated with antifungal drugs, such as voriconazole. However, the pharmacokinetics of voriconazole are variable between different animal and bird species. Therefore, the pharmacokinetics of voriconazole were investigated in this study in Magellanic penguins. Pharmacokinetic models were constructed and applied to predict the pharmacokinetics of voriconazole during long‐term treatment in Magellanic penguins, since the voriconazole treatment duration in chronic aspergillosis cases can last up to several months. Plasma voriconazole concentration–time data from adult Magellanic penguins (Spheniscus magellanicus; n = 15) following a single oral (PO) dose of either 2.5 mg/kg or 5 mg/kg in a herring in three separate study periods 7–12 months apart were collected. Mean plasma voriconazole concentrations were above the targeted MIC for Aspergillus fumigatus for 2 hr following a single 2.5 mg/kg voriconazole dose while the plasma concentrations exceeded the MIC for least 24 hr following a 5 mg/kg dose. Nonlinear mixed‐effects modeling was used to fit two pharmacokinetic models, one with first‐order and another with saturable elimination, to the single‐dose data. Fits were good for both, as long as dose was included as a covariate for the first‐order model so that clearance was lower and the half‐life longer for animals receiving the 5 mg/kg dose. Although the single‐dose data suggested saturated elimination at higher concentrations, the model with saturable elimination did not predict plasma voriconazole concentrations well for a clinical aspergillosis case receiving long‐term treatment, possibly because of induction of metabolizing enzymes with chronic exposure. Pharmacokinetic models should accurately predict plasma drug concentrations for different dosage regimens in order to be applicable in the field. Future studies should focus on determining clearance at steady‐state to be able to refine the pharmacokinetic models presented here and improve model performance for long‐term oral voriconazole administration in Magellanic penguins. 相似文献
78.
Pearce PD Ansari HA Maher DW Amarante MR Monro TL Hendrikse WL 《New Zealand veterinary journal》1997,45(2):69-71
A Robertsonian centric fusion between chromosomes 1 and 25 in Blonde d'Aquitaine cattle in New Zealand is reported. This fused chromosome is the same as the widely reported 1/29 translocation chromosome with the difference in the numbering arising from inconsistencies in the G and R-banded cattle karyotypes of the International System for Cytogenetic Nomenclature of Domestic Animals, 1989. 相似文献
79.
Sugars in the form of monosaccharides, oligosaccharides, polysaccharides and glycoconjugates (glycoproteins, glycolipids) are vital components of infecting microbes and host cells, and are involved in cell signalling associated with modulation of inflammation in all integumental structures. Indeed, sugars are the molecules most commonly involved in cell recognition and communication. In skin, they are essential to epidermal development and homeostasis. They play important roles in microbial adherence, colonization and biofilm formation, and in virulence. Two groups of pathogen recognition receptors, C-type lectins (CTL) and their receptors (CTLR), and the Toll-like receptors enable the host to recognize pathogen-associated molecular patterns (PAMPs), which are mainly glycolipids. The CTLs can recognize a wide variety of bacteria, fungi and parasites and are important in phagocytosis and endocytosis. TLRs are expressed on the surfaces of a variety of cells, including keratinocytes, dendritic cells, monocytes and macrophages; they play a major role in innate immunity. Interaction of TLRs with PAMPs initiates a cascade of events leading to production of reactive oxygen intermediates, cytokines and chemokines, and promotes inflammation. Exogenous sugars can block carbohydrate receptors and competitively displace bacteria from attachment to cells, including keratinocytes. Thus sugars may provide valuable adjunctive anti-inflammatory and/or antimicrobial treatment. A promising approach is the use of a panel of carbohydrate derivatives with anti-adhesive efficacy against bacteria frequently involved in diseases affecting skin and other epithelia. More complete characterization of sugar receptors and their ligands will provide further keys to use of carbohydrates in immunomodulation and infection control in skin. 相似文献
80.
Effects of stocking density,ration and temperature on growth,survival and metamorphosis of auricularia larvae of the California sea cucumber,Parastichopus californicus 下载免费PDF全文
The combined effects of stocking density (0.2, 0.5, 1, 2, 4 and 8 inds/ml) and dietary microalgal ration (20,000 and 40,000 cells/ml) and the sole effect of temperature (10, 12, 14, 16, 18 and 22°C) on the specific growth rate (SGR), per cent survival and per cent metamorphosis of auricularia larvae of the California sea cucumber, Parastichopus californicus, were evaluated in two separate experiments. The SGR was not significantly affected by stocking densities in the range of 0.2 to 4 inds/ml, but was significantly reduced at 8 inds/ml. The SGR of larvae fed 20,000 cells/ml was significantly reduced in comparison to those fed 40,000 cells/ml. Larvae had significantly higher per cent survival and per cent metamorphosis when reared at densities of 0.2 and 0.5 inds/ml compared with those reared at 2–8 inds/ml. Microalgal ration level did not significantly impact survival or metamorphosis. Larvae reared at 16 and 18°C had significantly higher SGRs and per cent metamorphosis than those held at all other temperatures, while per cent survival was highest at 16°C. Based on these results, we recommend rearing auricularia larvae of P. californicus at a stocking density at or below 0.5 inds/ml, a dietary ration of 40,000 cells/ml, and a temperature of 16°C. 相似文献